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Faculty - Clinical Psychology


Carrie Bearden [Edit Page]

Associate Professor in-Residence

Ph. D., University of Pennsylvania

Clinical Psychology


Contact Information

Office: 300 Medical Plaza, Rm 2265

Phone: x62983

E-mail: cbearden@mednet.ucla.edu



Research and Teaching Interests

The goals of my research program are to understand genetic, cognitive and neurobiological risk factors for the development of child- and adolescent-onset neuropsychiatric disorders. Dr. Bearden’s work examines these questions through two complementary lines of research: 1) The investigation of intermediate cognitive, neuroanatomic and temperament traits associated with the development of psychosis and /or mood disorder; and 2) The study of neurobehavioral manifestations of syndromes with an identified genetic origin. 

Much of this work to date has focused on the 22q11.2 Deletion Syndrome, a genetic disorder which results in a disruption of early neuronal migration and confers a particularly high risk for psychosis. Dr. Bearden’s research group has an ongoing study of autistic spectrum features in children with this syndrome, funded by the UCLA Center for Autism Research and Treatment (CART). This project involves comprehensive phenotyping (i.e., dimensional measures of autistic traits, neurocognition, and structural and functional neuroanatomy) which will be examined in relation to genetic variation at the 22q11.2 locus. 

In collaboration with Alcino Silva, Dr. Bearden’s lab is also now conducting translational studies of the neural basis of cognitive disability in children with another genetic disorder,Neurofibromatosis I, one of the most common single-gene disorders affecting neurologic function in humans.  This study represents one of the first translational clinical trials for developmental learning disabilities. 

Dr. Bearden is also a faculty member in the Brain Research Institute, and Associate Director of the Center for Assessment and Prevention of Prodromal States (CAPPS), a research clinic for adolescents at ultra-high risk for developing psychosis.


Biosketch/Curriculum Vitae

Dr. Carrie Bearden received her Ph.D. in Clinical Psychology from the University of Pennsylvania in 1999. From 2000 to 2001 she received training in adult and pediatric neuropsychology, during her internship at the San Diego VA Medical Center and UCSD Child & Adolescent Psychiatry Services. From 2001 to 2002, Dr. Bearden became a Postdoctoral Fellow under an NIMH Neuroscience Training Grant at the Childrens Hospital of Philadelphia, where she obtained further experience in pediatric cognitive neuroscience. Dr. Bearden joined the UCLA faculty as Assistant Professor in the Department of Psychiatry & Biobehavioral Sciences at UCLA in 2003. She holds a secondary appointment in the Department of Psychology. She has received numerous awards and honors, including Young Investigator Awards from the International Congress for Schizophrenia Research and the National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD), and the American College of Neuropsychopharmacology (ACNP), the A.E. Bennett Neuropsychiatric Research Award for Clinical Science in Biological Psychiatry, and the Samuel Gershon Junior Investigator Award from the International Society for Bipolar Disorders. Dr. Bearden’s research aims to understand genetic influences on brain structure in the development of psychosis, using converging methods to study cognition and neuroanatomy in clinical high-risk samples (e.g., adolescents at ultra high-risk for psychosis), and in possible ‘genetic subtypes’ of the disease with very high penetrance (e.g, 22q11.2 microdeletions). Another active research project, conducted in collaboration with Dr. Nelson Freimer, is an NIMH-funded study of neural endophenotypes of bipolar disorder in a genetically isolated population in Latin America.


Publications

Representative Publications

  1. Mittal VA, Daley M, Shiode MF, Bearden CE, O'Neill J, Cannon TD. Striatal volumes and dyskinetic movements in youth at high-risk for psychosis. Schizophr Res. 2010 Aug 21. [Epub ahead of print] PubMed PMID: 20732793.
  2. Yatham LN, Torres IJ, Malhi GS, Frangou S, Glahn DC, Bearden CE, Burdick KE, Martínez-Arán A, Dittmann S, Goldberg JF, Ozerdem A, Aydemir O, Chengappa KN. The International Society for Bipolar Disorders-Battery for Assessment of Neurocognition (ISBD-BANC). Bipolar Disord. 2010 Jun;12(4):351-63. PubMed PMID: 20636632.
  3. Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13141-6. Epub 2010 Jul 12. PubMed PMID: 20624961; PubMed Central PMCID: PMC2919968.
  4. Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF, Woods SW, Bearden CE, Christensen BK, Hawkins K, Heaton R, Keefe RS, Heinssen R, Cornblatt BA; North American Prodrome Longitudinal Study (NAPLS) Group. Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion  to psychosis. Arch Gen Psychiatry. 2010 Jun;67(6):578-88. PubMed PMID: 20530007.
  5. Mittal VA, Walker EF, Bearden CE, Walder D, Trottman H, Daley M, Simone A, Cannon TD. Markers of basal ganglia dysfunction and conversion to psychosis: neurocognitive deficits and dyskinesias in the prodromal period. Biol Psychiatry. 2010 Jul 1;68(1):93-9. Epub 2010 Mar 15. PubMed PMID: 20227679; PubMed Central PMCID: PMC2891189.
  6. Schlosser DA, Zinberg JL, Loewy RL, Casey-Cannon S, O'Brien MP, Bearden CE, Vinogradov S, Cannon TD. Predicting the longitudinal effects of the family environment on prodromal symptoms and functioning in patients at-risk for psychosis. Schizophr Res. 2010 May;118(1-3):69-75. Epub 2010 Feb 19. PubMed PMID: 20171848; PubMed Central PMCID: PMC2856759.
  7. Yee CM, Mathis KI, Sun JC, Sholty GL, Lang PJ, Bachman P, Williams TJ, Bearden CE, Cannon TD, Green MF, Subotnik KL, Ventura J, Nuechterlein KH. Integrity of emotional and motivational states during the prodromal, first-episode, and chronic phases of schizophrenia. J Abnorm Psychol. 2010 Feb;119(1):71-82. PubMed  PMID: 20141244; PubMed Central PMCID: PMC2853376.
  8. Glahn DC, Robinson JL, Tordesillas-Gutierrez D, Monkul ES, Holmes MK, Green MJ, Bearden CE. Fronto-temporal dysregulation in asymptomatic bipolar I patients: a paired associate functional MRI study. Hum Brain Mapp. 2010 Jul;31(7):1041-51.  PubMed PMID: 20063304.
  9. Sabb FW, van Erp TG, Hardt ME, Dapretto M, Caplan R, Cannon TD, Bearden CE. Language network dysfunction as a predictor of outcome in youth at clinical high  risk for psychosis. Schizophr Res. 2010 Feb;116(2-3):173-83. Epub 2009 Oct 27. PubMed PMID: 19861234; PubMed Central PMCID: PMC2818263.
  10. Bearden CE, Thompson PM, Avedissian C, Klunder AD, Nicoletti M, Dierschke N,  Brambilla P, Soares JC. Altered hippocampal morphology in unmedicated patients with major depressive illness. ASN Neuro. 2009 Nov 10;1(4). pii: e00020. doi: 10.1042/AN20090026. PubMed PMID: 19843010; PubMed Central PMCID: PMC2785515.
  11. Sun D, van Erp TG, Thompson PM, Bearden CE, Daley M, Kushan L, Hardt ME, Nuechterlein KH, Toga AW, Cannon TD. Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms. Biol Psychiatry. 2009 Dec 1;66(11):1055-60. Epub 2009 Sep 3. PubMed PMID: 19729150.
  12. Sanz JH, Karlsgodt KH, Bearden CE, van Erp TG, Nandy RR, Ventura J, Nuechterlein K, Cannon TD. Symptomatic and functional correlates of regional brain physiology during working memory processing in patients with recent onset schizophrenia. Psychiatry Res. 2009 Sep 30;173(3):177-82. Epub 2009 Aug 18. PubMed PMID: 19692211; PubMed Central PMCID: PMC2734873.
  13. Niendam TA, Jalbrzikowski M, Bearden CE. Exploring predictors of outcome in the psychosis prodrome: implications for early identification and intervention. Neuropsychol Rev. 2009 Sep;19(3):280-93. Epub 2009 Jul 14. Review. PubMed PMID: 19597747; PubMed Central PMCID: PMC2745530.
  14. Robinson JL, Bearden CE, Monkul ES, Tordesillas-Gutiérrez D, Velligan DI, Frangou S, Glahn DC. Fronto-temporal dysregulation in remitted bipolar patients:  an fMRI delayed-non-match-to-sample (DNMS) study. Bipolar Disord. 2009 Jun;11(4):351-60. PubMed PMID: 19500088.
  15. Karlsgodt KH, Niendam TA, Bearden CE, Cannon TD. White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis. Biol Psychiatry. 2009 Sep 15;66(6):562-9. Epub 2009 May 7. PubMed PMID: 19423081; PubMed Central PMCID: PMC2805703.
  16. Bearden CE, Jasinska AJ, Freimer NB. Methodological issues in molecular genetic studies of mental disorders. Annu Rev Clin Psychol. 2009;5:49-69. Review. PubMed PMID: 19327025.
  17. Karlsgodt KH, Sanz J, van Erp TG, Bearden CE, Nuechterlein KH, Cannon TD. Re-evaluating dorsolateral prefrontal cortex activation during working memory in  schizophrenia. Schizophr Res. 2009 Mar;108(1-3):143-50. Epub 2009 Feb 3. PubMed PMID: 19196494; PubMed Central PMCID: PMC2671001.
  18. Kathleen Holmes M, Bearden CE, Barguil M, Fonseca M, Serap Monkul E, Nery FG, Soares JC, Mintz J, Glahn DC. Conceptualizing impulsivity and risk taking in bipolar disorder: importance of history of alcohol abuse. Bipolar Disord. 2009 Feb;11(1):33-40. PubMed PMID: 19133964.
  19. Niendam TA, Berzak J, Cannon TD, Bearden CE. Obsessive compulsive symptoms in the psychosis prodrome: correlates of clinical and functional outcome. Schizophr  Res. 2009 Mar;108(1-3):170-5. Epub 2008 Dec 20. PubMed PMID: 19097751; PubMed Central PMCID: PMC2670932. 
  20. O'Brien MP, Zinberg JL, Ho L, Rudd A, Kopelowicz A, Daley M, Bearden CE, Cannon TD. Family problem solving interactions and 6-month symptomatic and functional outcomes in youth at ultra-high risk for psychosis and with recent onset psychotic symptoms: a longitudinal study. Schizophr Res. 2009 Feb;107(2-3):198-205. Epub 2008 Nov 8. PubMed PMID: 18996681; PubMed Central PMCID: PMC2737734.
  21. Robinson JL, Monkul ES, Tordesillas-Gutiérrez D, Franklin C, Bearden CE, Fox  PT, Glahn DC. Fronto-limbic circuitry in euthymic bipolar disorder: evidence for  prefrontal hyperactivation. Psychiatry Res. 2008 Nov 30;164(2):106-13. Epub 2008  Oct 19. PubMed PMID: 18930635.
  22. Willhite RK, Niendam TA, Bearden CE, Zinberg J, O'Brien MP, Cannon TD. Gender differences in symptoms, functioning and social support in patients at ultra-high risk for developing a psychotic disorder. Schizophr Res. 2008 Sep;104(1-3):237-45. Epub 2008 Jun 24. PubMed PMID: 18573639; PubMed Central PMCID: PMC2612126.
  23. Bearden CE, van Erp TG, Dutton RA, Lee AD, Simon TJ, Cannon TD, Emanuel BS, McDonald-McGinn D, Zackai EH, Thompson PM. Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletions. Cereb Cortex. 2009 Jan;19(1):115-26. Epub 2008 May 14. PubMed PMID: 18483006; PubMed Central PMCID: PMC2733329.
  24. Bearden CE, Glahn DC, Lee AD, Chiang MC, van Erp TG, Cannon TD, Reiss AL, Toga AW, Thompson PM. Neural phenotypes of common and rare genetic variants. Biol Psychol. 2008 Sep;79(1):43-57. Epub 2008 Feb 23. Review. PubMed PMID: 18395317; PubMed Central PMCID: PMC2535822.
  25. Bearden CE, Soares JC, Klunder AD, Nicoletti M, Dierschke N, Hayashi KM, Narr KL, Brambilla P, Sassi RB, Axelson D, Ryan N, Birmaher B, Thompson PM. Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2008 May;47(5):515-25. PubMed PMID: 18356767; PubMed Central PMCID: PMC2773145.
  26. Sabb FW, Bearden CE, Glahn DC, Parker DS, Freimer N, Bilder RM. A collaborative knowledge base for cognitive phenomics. Mol Psychiatry. 2008 Apr;13(4):350-60. Epub 2008 Jan 8. PubMed PMID: 18180765.
  27. Bearden CE, Glahn DC, Caetano S, Olvera RL, Fonseca M, Najt P, Hunter K, Pliszka SR, Soares JC. Evidence for disruption in prefrontal cortical functions in juvenile bipolar disorder. Bipolar Disord. 2007 Jun;9 Suppl 1:145-59. PubMed PMID: 17543033.
  28. van Erp TG, Lesh TA, Knowlton BJ, Bearden CE, Hardt M, Karlsgodt KH, Shirinyan D, Rao V, Green MF, Subotnik KL, Nuechterlein K, Cannon TD. Remember and know judgments during recognition in chronic schizophrenia. Schizophr Res. 2008 Mar;100(1-3):181-90. Epub 2007 Oct 26. PubMed PMID: 17964760; PubMed Central PMCID: PMC2517628.
  29. Altshuler LL, Bearden CE, Green MF, van Gorp W, Mintz J. A relationship between neurocognitive impairment and functional impairment in bipolar disorder:  a pilot study. Psychiatry Res. 2008 Jan 15;157(1-3):289-93. Epub 2007 Sep 14. PubMed PMID: 17868903.
  30. Karlsgodt KH, van Erp TG, Poldrack RA, Bearden CE, Nuechterlein KH, Cannon TD. Diffusion tensor imaging of the superior longitudinal fasciculus and working  memory in recent-onset schizophrenia. Biol Psychiatry. 2008 Mar 1;63(5):512-8. Epub 2007 Aug 27. PubMed PMID: 17720147.
  31. Bearden CE, Thompson PM, Dutton RA, Frey BN, Peluso MA, Nicoletti M, Dierschke N, Hayashi KM, Klunder AD, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Soares JC. Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder. Neuropsychopharmacology. 2008 May;33(6):1229-38. Epub 2007 Aug 8. PubMed PMID: 17687266.
  32. Glahn DC, Bearden CE, Barguil M, Barrett J, Reichenberg A, Bowden CL, Soares  JC, Velligan DI. The neurocognitive signature of psychotic bipolar disorder. Biol Psychiatry. 2007 Oct 15;62(8):910-6. Epub 2007 Jun 1. PubMed PMID: 17543288.
  33. Niendam TA, Horwitz J, Bearden CE, Cannon TD. Ecological assessment of executive dysfunction in the psychosis prodrome: a pilot study. Schizophr Res. 2007 Jul;93(1-3):350-4. Epub 2007 Apr 30. PubMed PMID: 17467957; PubMed Central PMCID: PMC2045154.
  34. Cornblatt BA, Auther AM, Niendam T, Smith CW, Zinberg J, Bearden CE, Cannon TD. Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia. Schizophr Bull. 2007 May;33(3):688-702. Epub 2007 Apr 17. PubMed PMID: 17440198; PubMed Central PMCID: PMC2526147.
  35. Bearden CE, van Erp TG, Thompson PM, Toga AW, Cannon TD. Cortical mapping of  genotype-phenotype relationships in schizophrenia. Hum Brain Mapp. 2007 Jun;28(6):519-32. Review. PubMed PMID: 17437284.
  36. Niendam TA, Bearden CE, Zinberg J, Johnson JK, O'Brien M, Cannon TD. The course of neurocognition and social functioning in individuals at ultra high risk for psychosis. Schizophr Bull. 2007 May;33(3):772-81. Epub 2007 Apr 9. PubMed PMID: 17420177; PubMed Central PMCID: PMC2526130.
  37. Bearden CE, Thompson PM, Dalwani M, Hayashi KM, Lee AD, Nicoletti M, Trakhtenbroit M, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Soares JC. Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol Psychiatry. 2007 Jul 1;62(1):7-16. Epub 2007 Jan 19.  PubMed PMID: 17240360.
  38. Bearden CE, van Erp TG, Dutton RA, Tran H, Zimmermann L, Sun D, Geaga JA, Simon TJ, Glahn DC, Cannon TD, Emanuel BS, Toga AW, Thompson PM. Mapping cortical thickness in children with 22q11.2 deletions. Cereb Cortex. 2007 Aug;17(8):1889-98. Epub 2006 Oct 20. PubMed PMID: 17056649; PubMed Central PMCID: PMC2819929.
  39. Glahn DC, Barrett J, Bearden CE, Mintz J, Green MF, Serap Monkul E, Najt P, Soares JC, Velligan DI. Dissociable mechanisms for memory impairment in bipolar disorder and schizophrenia. Psychol Med. 2006 Aug;36(8):1085-95. Epub 2006 May 31. PubMed PMID: 16734948.
  40. Bearden CE, Freimer NB. Endophenotypes for psychiatric disorders: ready for primetime? Trends Genet. 2006 Jun;22(6):306-13. Epub 2006 May 11. PubMed PMID: 16697071.

Faculty Awards