Director, Center for the Assessment and Prevention of Prodromal States
Ph.D.: University of Pennsylvania
Primary Area: Clinical Psychology
Home Department: Psychiatry and Biobehavioral Sciences
Address: A7-460 Semel Institute
Research and Teaching Interests:
The goals of my research program are to understand early risk factors for developmental neuropsychiatric disorders. My lab examines these questions through two complementary lines of research:
- The investigation of intermediate neurobehavioral traits associated with the development of serious mental illness; and
- The study of rare, highly penetrant neurogenetic disorders.
Much of this work has focused on the 22q11.2 Deletion Syndrome, a genetic disorder which results in a disruption of early neuronal migration and confers a particularly high risk for psychosis. Dr. Bearden leads the 22q11 working group of the ENIGMA consortium. Her research group has an ongoing longitudinal study of youth with Chromosome 22q11.2 copy number variation, and is also part of the global Genes to Mental Health network.
Dr. Bearden is the Director of the UCLA Center for Assessment and Prevention of Prodromal States (CAPPS; https://www.cappsucla.org), a clinical research program for youth at high risk for developing psychosis. She is a Principal Investigator of the new international Accelerating Medicines Partnership – Schizophrenia (AMP-SCZ). She is a faculty member in the UCLA Brain Research Institute, and co-directs the Neurogenetics T32 Predoctoral Training Program within the Integrative Center for Neurogenetics.
Dr. Carrie Bearden received her Ph.D. in Clinical Psychology from the University of Pennsylvania. She completed her clinical internship at the San Diego VA Medical Center and UCSD Child & Adolescent Psychiatry Services. Dr. Bearden joined the UCLA faculty in the Department of Psychiatry & Biobehavioral Sciences at UCLA in 2003. Currently, she is a Professor in the Semel Institute for Neuroscience and Human Behavior and Brain Research Institute, with a joint appointment in the Department of Psychology. Dr. Bearden’s research aims to understand neurobiological risk factors for the development of serious mental illness in youth, using converging methods to study cognition and neuroanatomy in clinical high-risk cohorts (e.g., adolescents with early symptoms of psychosis), and in highly penetrant genetic conditions , particularly 22q11.2 mutations. Her recent work focuses on translational approaches to understanding disrupted brain circuitry in developmental neuropsychiatric disorders, particularly in the context of rare genetic disorders. In collaboration with Dr. Nelson Freimer, she is also conducting an NIMH-funded study of the genetics of serious mental illness in Latin America.
Dr. Bearden is the Assistant Editor of Biological Psychiatry, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, and Schizophrenia Bulletin. She is a Fellow of the American College of Neuropsychopharmacology and the Association for Psychological Science, and chairs the DSM-V Serious Mental Disorders Committee and the Women’s Leadership Group of the Society of Biological Psychiatry. Dr. Bearden has received numerous awards and honors, both for her research achievements and for teaching and mentorship, including Young Investigator Awards from the International Congress for Schizophrenia Research and the National Alliance for Research on Schizophrenia and Affective Disorders (NARSAD), and ACNP, the A.E. Bennett Neuropsychiatric Research Award for Clinical Science in Biological Psychiatry, and the Joel Elkes Research Award for Outstanding Contributions to Neuropsychopharmacology.
- Shilyansky C, Karlsgodt KH, Cummings DM, Sidiropoulou K, Hardt M, James AS, Ehninger D, Bearden CE, Poirazi P, Jentsch JD, Cannon TD, Levine MS, Silva AJ. Neurofibromin regulates corticostriatal inhibitory networks during working memory performance. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13141-6. Epub 2010 Jul 12. PubMed PMID: 20624961; PubMed Central PMCID: PMC2919968.
- Seidman LJ, Giuliano AJ, Meyer EC, Addington J, Cadenhead KS, Cannon TD, McGlashan TH, Perkins DO, Tsuang MT, Walker EF, Woods SW, Bearden CE, Christensen BK, Hawkins K, Heaton R, Keefe RS, Heinssen R, Cornblatt BA; North American Prodrome Longitudinal Study (NAPLS) Group. Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis. Arch Gen Psychiatry. 2010 Jun;67(6):578-88. PubMed PMID: 20530007.
- Mittal VA, Walker EF, Bearden CE, Walder D, Trottman H, Daley M, Simone A, Cannon TD. Markers of basal ganglia dysfunction and conversion to psychosis: neurocognitive deficits and dyskinesias in the prodromal period. Biol Psychiatry. 2010 Jul 1;68(1):93-9. Epub 2010 Mar 15. PubMed PMID: 20227679; PubMed Central PMCID: PMC2891189.
- Glahn DC, Robinson JL, Tordesillas-Gutierrez D, Monkul ES, Holmes MK, Green MJ, Bearden CE. Fronto-temporal dysregulation in asymptomatic bipolar I patients: a paired associate functional MRI study. Hum Brain Mapp. 2010 Jul;31(7):1041-51. PubMed PMID: 20063304.
- Sabb FW, van Erp TG, Hardt ME, Dapretto M, Caplan R, Cannon TD, Bearden CE. Language network dysfunction as a predictor of outcome in youth at clinical high risk for psychosis. Schizophr Res. 2010 Feb;116(2-3):173-83. Epub 2009 Oct 27. PubMed PMID: 19861234; PubMed Central PMCID: PMC2818263.
- Sun D, van Erp TG, Thompson PM, Bearden CE, Daley M, Kushan L, Hardt ME, Nuechterlein KH, Toga AW, Cannon TD. Elucidating a magnetic resonance imaging-based neuroanatomic biomarker for psychosis: classification analysis using probabilistic brain atlas and machine learning algorithms. Biol Psychiatry. 2009 Dec 1;66(11):1055-60. Epub 2009 Sep 3. PubMed PMID: 19729150.
- Niendam TA, Jalbrzikowski M, Bearden CE. Exploring predictors of outcome in the psychosis prodrome: implications for early identification and intervention. Neuropsychol Rev. 2009 Sep;19(3):280-93. Epub 2009 Jul 14. Review. PubMed PMID: 19597747; PubMed Central PMCID: PMC2745530.
- Karlsgodt KH, Niendam TA, Bearden CE, Cannon TD. White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis. Biol Psychiatry. 2009 Sep 15;66(6):562-9. Epub 2009 May 7. PubMed PMID: 19423081; PubMed Central PMCID: PMC2805703.
- Bearden CE, Jasinska AJ, Freimer NB. Methodological issues in molecular genetic studies of mental disorders. Annu Rev Clin Psychol. 2009;5:49-69. Review. PubMed PMID: 19327025.
- Karlsgodt KH, Sanz J, van Erp TG, Bearden CE, Nuechterlein KH, Cannon TD. Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia. Schizophr Res. 2009 Mar;108(1-3):143-50. Epub 2009 Feb 3. PubMed PMID: 19196494; PubMed Central PMCID: PMC2671001.
- Bearden CE, van Erp TG, Dutton RA, Lee AD, Simon TJ, Cannon TD, Emanuel BS, McDonald-McGinn D, Zackai EH, Thompson PM. Alterations in midline cortical thickness and gyrification patterns mapped in children with 22q11.2 deletions. Cereb Cortex. 2009 Jan;19(1):115-26. Epub 2008 May 14. PubMed PMID: 18483006; PubMed Central PMCID: PMC2733329.
- Bearden CE, Glahn DC, Lee AD, Chiang MC, van Erp TG, Cannon TD, Reiss AL, Toga AW, Thompson PM. Neural phenotypes of common and rare genetic variants. Biol Psychol. 2008 Sep;79(1):43-57. Epub 2008 Feb 23. Review. PubMed PMID: 18395317; PubMed Central PMCID: PMC2535822.
- Bearden CE, Soares JC, Klunder AD, Nicoletti M, Dierschke N, Hayashi KM, Narr KL, Brambilla P, Sassi RB, Axelson D, Ryan N, Birmaher B, Thompson PM. Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2008 May;47(5):515-25. PubMed PMID: 18356767; PubMed Central PMCID: PMC2773145.
- Sabb FW, Bearden CE, Glahn DC, Parker DS, Freimer N, Bilder RM. A collaborative knowledge base for cognitive phenomics. Mol Psychiatry. 2008 Apr;13(4):350-60. Epub 2008 Jan 8. PubMed PMID: 18180765.
- Karlsgodt KH, van Erp TG, Poldrack RA, Bearden CE, Nuechterlein KH, Cannon TD. Diffusion tensor imaging of the superior longitudinal fasciculus and working memory in recent-onset schizophrenia. Biol Psychiatry. 2008 Mar 1;63(5):512-8. Epub 2007 Aug 27. PubMed PMID: 17720147.
- Bearden CE, Thompson PM, Dutton RA, Frey BN, Peluso MA, Nicoletti M, Dierschke N, Hayashi KM, Klunder AD, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Soares JC. Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder. Neuropsychopharmacology. 2008 May;33(6):1229-38. Epub 2007 Aug 8. PubMed PMID: 17687266.
- Glahn DC, Bearden CE, Barguil M, Barrett J, Reichenberg A, Bowden CL, Soares JC, Velligan DI. The neurocognitive signature of psychotic bipolar disorder. Biol Psychiatry. 2007 Oct 15;62(8):910-6. Epub 2007 Jun 1. PubMed PMID: 17543288.
- Cornblatt BA, Auther AM, Niendam T, Smith CW, Zinberg J, Bearden CE, Cannon TD. Preliminary findings for two new measures of social and role functioning in the prodromal phase of schizophrenia. Schizophr Bull. 2007 May;33(3):688-702. Epub 2007 Apr 17. PubMed PMID: 17440198; PubMed Central PMCID: PMC2526147.
- Bearden CE, van Erp TG, Thompson PM, Toga AW, Cannon TD. Cortical mapping of genotype-phenotype relationships in schizophrenia. Hum Brain Mapp. 2007 Jun;28(6):519-32. Review. PubMed PMID: 17437284.
- Bearden CE, Thompson PM, Dalwani M, Hayashi KM, Lee AD, Nicoletti M, Trakhtenbroit M, Glahn DC, Brambilla P, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Soares JC. Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biol Psychiatry. 2007 Jul 1;62(1):7-16. Epub 2007 Jan 19. PubMed PMID: 17240360.
- Bearden CE, van Erp TG, Dutton RA, Tran H, Zimmermann L, Sun D, Geaga JA, Simon TJ, Glahn DC, Cannon TD, Emanuel BS, Toga AW, Thompson PM. Mapping cortical thickness in children with 22q11.2 deletions. Cereb Cortex. 2007 Aug;17(8):1889-98. Epub 2006 Oct 20. PubMed PMID: 17056649; PubMed Central PMCID: PMC2819929.
- Bearden CE, Freimer NB. Endophenotypes for psychiatric disorders: ready for primetime? Trends Genet. 2006 Jun;22(6):306-13. Epub 2006 May 11. PubMed PMID: 16697071.
- Bearden CE. Same DNA Deletion Paves Paths to Schizophrenia, Autism. Viewpoint, Spectrum News.https://spectrumnews.org/opinion/viewpoint/dna-deletion-paves-paths-autism-schizophrenia/
- Bearden CE. Getting Off Tract: Developmental Disruptions of White Matter in Youth With Bipolar Disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 2018;57(2):82]
- Bearden CE. Accelerating the Bending Arc Toward Equality: A Commentary on Gender Trends in Authorship in Psychiatry Journals. Biol Psychiatry. 2019 Oct 15;86(8):575-576. doi: 10.1016/j.biopsych.2019.08.003. PMID: 31558220.
- Bearden CE, Forsyth JK. The many roads to psychosis: recent advances in understanding risk and mechanisms. F1000Res. 2018 Dec 3;7:F1000 Faculty Rev-1883. doi: 10.12688/f1000research.16574.1. PMID: 30631427; PMCID: PMC6281008.
- Bearden CE, Karlsgodt KH. Risk and Resilience in Extraordinary Times. Biol Psychiatry Cogn Neurosci Neuroimaging. 2021 Feb;6(2):136-138. doi: 10.1016/j.bpsc.2020.12.001. PMID: 33558037.
Prioritizing Genetic Contributors to Cortical Alterations in 22q11.2 Deletion Syndrome Using Imaging Transcriptomics.Cereb Cortex. 2021 Jun 10;31(7):3285-3298. doi: 10.1093/cercor/bhab008.PMID: 33638978Structural and functional brain alterations revealed by neuroimaging in CNV carriers.Curr Opin Genet Dev. 2021 Jun;68:88-98. doi: 10.1016/j.gde.2021.03.002. Epub 2021 Mar 31.PMID: 33812299 Review.Social cognition in 22q11.2 deletion syndrome and idiopathic developmental neuropsychiatric disorders.J Neurodev Disord. 2021 Apr 17;13(1):15. doi: 10.1186/s11689-021-09363-4.PMID: 33863277Harnessing rare variants in neuropsychiatric and neurodevelopment disorders-a Keystone Symposia report.Ann N Y Acad Sci. 2021 Dec;1506(1):5-17. doi: 10.1111/nyas.14658. Epub 2021 Aug 2.PMID: 34342000Family-focused therapy for individuals at high clinical risk for psychosis: A confirmatory efficacy trial.Early Interv Psychiatry. 2021 Aug 23. doi: 10.1111/eip.13208. Online ahead of print.PMID: 34427047Sleep Disturbance in Individuals at Clinical High Risk for Psychosis.Schizophr Bull. 2021 Sep 18:sbab104. doi: 10.1093/schbul/sbab104. Online ahead of print.PMID: 34536012The prediction-error hypothesis of schizophrenia: new data point to circuit-specific changes in dopamine activity.Neuropsychopharmacology. 2021 Sep 29. doi: 10.1038/s41386-021-01188-y. PMID: 34588607Opposing white matter microstructure abnormalities in 22q11.2 deletion and duplication carriers.Transl Psychiatry. 2021 Nov 10;11(1):580. doi: 10.1038/s41398-021-01703-1.PMID: 34759270Transcriptomic profiling of whole blood in 22q11.2 reciprocal copy number variants reveals that cell proportion highly impacts gene expression.Brain Behav Immun Health. 2021 Nov 9;18:100386. doi: 10.1016/j.bbih.2021.100386. .PMID: 34841284
Bearden lab website