David Clewett • UCLA Department of Psychology

August 6, 2021

dclewett316

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Assistant Professor
Ph.D.: University of Southern California
Primary Area: Cognitive Psychology
Secondary Area: Behavioral Neuroscience
Email: david.clewett@psych.ucla.edu

Research and Teaching Interests:

In everyday life, we encounter a continuous stream of information. Yet, because our mental resources are limited, we cannot process and remember everything we experience. This raises two critical questions: How do we prioritize and store important information in memory? As time unfold, how do our experiences become organized into memories of meaningful events? My research examines the brain mechanisms that support these adaptive memory processes.

A key theoretical construct motivating my work is that physiological arousal plays a fundamental role in facilitating attention and memory. Decades of research show that people perceive and remember emotionally arousing events better than more mundane events. For example, experiencing a car crash or celebrating a birthday tend to be more memorable than a routine commute to work. Beyond simply enhancing processing of the emotional information, however, a surge in arousal can also spillover to enhance or impair processing of nearby neutral information. Spikes in arousal are also happening all the time and not just in response to emotional events. Consequently, even as everyday experiences unfold, arousal states may play a lead role in determining whether an event will be forgotten or etched into memory more permanently.

The goal of our research is to promote a deeper understanding of how stress and emotion shape the content and structure of memory. We are especially interested in uncovering arousal-related brain mechanisms that support the formation and retrieval of important events. To study these topics, my lab takes a multi-modal approach that includes functional and structural neuroimaging (fMRI/MRI/DTI), neurophysiology (eye tracking, pupillometry), and behavioral methods. Professor Clewett’s lab site

Biography:

Dr. Clewett received his PhD in Neuroscience from the University of Southern California in 2016, where he worked with Dr. Mara Mather to study emotion-cognition interactions. He then conducted a postdoctoral fellowship with Dr. Lila Davachi at NYU and Columbia University, where he studied how episodic memories are constructed from continuous experience. Before attending graduate school, he received a B.S. degree in Biopsychology with a minor in English from the University of California, Santa Barbara.

Representative Publications:

Clewett, D., Gasser, C., & Davachi, L. (2020). Pupil-linked arousal signals track the temporal organization of events in memory. Nature communications, 11(1), 1-14.
Clewett, D., Dunsmoor, J., Bachman, S., Phelps, E., & Davachi, L. (in press). Survival of the salient: Aversive learning rescues otherwise forgettable memories via neural reactivation and post-encoding hippocampal connectivity. https://www.biorxiv.org/content/10.1101/2020.07.07.192252v1
Clewett, D., Dubrow, S., & Davachi, L. (2019). Transcending time in the brain: How event memories emerge from experience. Hippocampus, 29(3), 162-183.
Clewett, D., Huang, R., Velasco, R., Lee, T.H., & Mather, M. (2018). Locus coeruleus activity strengthens prioritized memories under arousal. Journal of Neuroscience, 38(6), 1558-1574.
Clewett, D., & Davachi, L. (2017). The ebb and flow of experience determines the temporal structure of memory. Current Opinion in Behavioral Sciences, 17, 186-193.
Clewett, D., Sakaki, M., Huang, R., Nielsen, S., & Mather, M. (2017). Arousal amplifies biased competition between high and low priority memories more in women than in men: the role of elevated noradrenergic activity. Psychoneuroendocrinology, 80, 80-91.
Clewett, D., Sakaki, M., Nielsen, S., Petzinger, G., & Mather, M. (2017). Noradrenergic mechanisms of arousal’s bidirectional effects on episodic memory. Neurobiology of Learning and Memory, 137, 1-14.
Mather, M., Clewett, D., Sakaki, M., & Harley, C. (2015). Norepinephrine ignites local hot spots of neuronal excitation: How arousal amplifies selectivity in perception and memory. Behavioral and Brain Sciences, 1-100.